IL12RB2 antibody (AA 420-620)

Catalog No. ABIN6142303

This anti-IL12RB2 antibody is a Rabbit Polyclonal antibody detecting IL12RB2 in WB. Suitable for Human.

Quick Overview for IL12RB2 antibody (AA 420-620) (ABIN6142303)

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL12RB2 Antibody

Binding Specificity: AA 420-620

Sequence: GLLAPRQVSA NSEGMDNILV TWQPPRKDPS AVQEYVVEWR ELHPGGDTQV PLNWLRSRPY NVSALISENI KSYICYEIRV YALSGDQGGC SSILGNSKHK APLSGPHINA ITEEKGSILI SWNSIPVQEQ MGCLLHYRIY WKERDSNSQP QLCEIPYRVS QNSHPINSLQ PRVTYVLWMT ALTAAGESSH GNEREFCLQG K

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human IL12RB2 (NP_001550.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IL12RB2

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Alternative Name: IL12RB2

Background: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.,IL12RB2,Cancer,Tumor immunology,Immunology & Inflammation,Cytokines,Interleukins,Cell Intrinsic Innate Immunity Signaling Pathway,IL12RB2

Molecular Weight: 74 kDa/87 kDa/97 kDa

Gene ID: 3595

UniProt: Q99665

Pathways: JAK-STAT Signaling