IL17RA antibody (AA 697-866)

Catalog No. ABIN6142322

This Rabbit Polyclonal antibody specifically detects IL17RA in WB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for IL17RA antibody (AA 697-866) (ABIN6142322)

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL17RA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL17RA Antibody

Binding Specificity: AA 697-866

Sequence: AGEGEACPLL GSPGAGRNSV LFLPVDPEDS PLGSSTPMAS PDLLPEDVRE HLEGLMLSLF EQSLSCQAQG GCSRPAMVLT DPHTPYEEEQ RQSVQSDQGY ISRSSPQPPE GLTEMEEEEE EEQDPGKPAL PLSPEDLESL RSLQRQLLFR QLQKNSGWDT MGSESEGPSA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 697-866 of human IL17RA (NP_055154.3).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-IL17RA antibody (ABIN6142322)

Ganesan, Rasool: "Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis." in: Molecular immunology, Vol. 91, pp. 134-144, (2017) (PubMed).

Target Details for IL17RA

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Alternative Name: IL17RA

Background: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor, IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.,IL17RA,CANDF5,CD217,CDw217,IL-17RA,IL17R,IMD51,hIL-17R,Immunology & Inflammation,CD markers,Cytokines,Interleukins,Cell Intrinsic Innate Immunity Signaling Pathway,IL17RA

Molecular Weight: 92 kDa/96 kDa

Gene ID: 23765

UniProt: Q96F46

Pathways: SARS-CoV-2 Protein Interactome