INCENP antibody (AA 785-914)

Catalog No. ABIN6142441

This Rabbit Polyclonal antibody specifically detects INCENP in WB. It exhibits reactivity toward Human.

Quick Overview for INCENP antibody (AA 785-914) (ABIN6142441)

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INCENP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-INCENP Antibody

Binding Specificity: AA 785-914

Sequence: ALNVTVDVQS PACTSYQMTP QGHRAPPKIN PDNYGMDLNS DDSTDDEAHP RKPIPTWARG TPLSQAIIHQ YYHPPNLLEL FGTILPLDLE DIFKKSKPRY HKRTSSAVWN SPPLQGARVP SSLAYSLKKH

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 785-914 of human INCENP (NP_064623.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for INCENP

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Alternative Name: INCENP

Background: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008],INCENP,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centromere,INCENP

Molecular Weight: 104 kDa/105 kDa

Gene ID: 3619

UniProt: Q9NQS7

Pathways: Cell Division Cycle