Importin 9 antibody (AA 827-1041)

Catalog No. ABIN6142507

The Rabbit Polyclonal anti-Importin 9 antibody has been validated for WB and IF. It is suitable to detect Importin 9 in samples from Human.

Quick Overview for Importin 9 antibody (AA 827-1041) (ABIN6142507)

Target: Importin 9 (IPO9)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 9 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Importin 9 Antibody

Binding Specificity: AA 827-1041

Sequence: LPGPTGKPAL EFVMAEWTSR QHLFYGQYEG KVSSVALCKL LQHGINADDK RLQDIRVKGE EIYSMDEGIR TRSKSAKNPE RWTNIPLLVK ILKLIINELS NVMEANAARQ ATPAEWSQDD SNDMWEDQEE EEEEEEDGLA GQLLSDILAT SKYEEDYYED DEEDDPDALK DPLYQIDLQA YLTDFLCQFA QQPCYIMFSG HLNDNERRVL QTIGI

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 827-1041 of human IPO9 (NP_060555.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Importin 9

Target: Importin 9 (IPO9)

Alternative Name: IPO9

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. Mediates the nuclear import of actin (By similarity.,IPO9,Imp9,IPO9

Molecular Weight: 115 kDa

Gene ID: 55705

UniProt: Q96P70

Pathways: Protein targeting to Nucleus