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MCAM antibody (AA 447-646)

Name: MCAM antibody (AA 447-646)
Brand: antibodies-online
SKU: ABIN6143621
Price: 877.74 USD
Availability: InStock

MCAM Reactivity: Human IHC, WB, IF Host: Rabbit Polyclonal unconjugated

Immunohistochemistry of paraffin-embedded human lung cancer using CD146/MCAM Rabbit pAb (ABIN6127568, ABIN6143621, ABIN6143622 and ABIN6218100) at dilution of 1:25 (40x lens). (MCAM antibody (AA 447-646))

IHC

Immunofluorescence analysis of cells using CD146/MCAM Rabbit pAb (ABIN6127568, ABIN6143621, ABIN6143622 and ABIN6218100) at dilution of 1:50 (40x lens). (MCAM antibody (AA 447-646))

Western blot analysis of extracts of various cell lines, using CD146/MCAM antibody (ABIN6127568, ABIN6143621, ABIN6143622 and ABIN6218100) at 1:500 dilution. (MCAM antibody (AA 447-646))

Immunohistochemistry of paraffin-embedded human colon carcinoma using CD146/MCAM Rabbit pAb (ABIN6127568, ABIN6143621, ABIN6143622 and ABIN6218100) at dilution of 1:25 (40x lens). (MCAM antibody (AA 447-646))

IHC

Immunofluorescence analysis of HeLa cells using CD146/MCAM Rabbit pAb (ABIN6127568, ABIN6143621, ABIN6143622 and ABIN6218100) at dilution of 1:50 (40x lens). (MCAM antibody (AA 447-646))

Immunohistochemistry of paraffin-embedded human lung using CD146/MCAM Rabbit pAb (ABIN6127568, ABIN6143621, ABIN6143622 and ABIN6218100) at dilution of 1:25 (40x lens). (MCAM antibody (AA 447-646))

IHC

7 images

Catalog No. ABIN6143621

Datasheet as PDF

Target See all MCAM Antibodies

MCAM (Melanoma Cell Adhesion Molecule (MCAM))
Binding Specificity
16

9

7

6

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 447-646
Reactivity
117

47

46

14

13

8

8

6

5

2
Human
Host
89

52

1

1

1
Rabbit
Compatible Secondaries
Clonality
81

63
Polyclonal
Conjugate
67

12

11

9

3

3

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MCAM antibody is un-conjugated
Application
78

65

58

36

18

17

14

11

10

5

4

4

3

3

2

1

1

1
Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Sequence

VLNLSCEASG HPRPTISWNV NGTASEQDQD PQRVLSTLNV LVTPELLETG VECTASNDLG KNTSILFLEL VNLTTLTPDS NTTTGLSTST ASPHTRANST STERKLPEPE SRGVVIVAVI VCILVLAVLG AVLYFLYKKG KLPCRRSGKQ EITLPPSRKS ELVVEVKSDK LPEEMGLLQG SSGDKRAPGD QGEKYIDLRH

Cross-Reactivity

Human, Mouse, Rat

Characteristics

Polyclonal Antibodies

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 447-646 of human CD146/CD146/MCAM (NP_006491.2).

Isotype

IgG

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Application Notes

WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions

For Research Use only
Format

Liquid

Buffer

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20°C. Avoid freeze / thaw cycles.
Target

MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Alternative Name

MCAM (MCAM Products)

Background

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.,MCAM,CD146,MUC18,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cell Adhesion Molecules,Cytoskeleton,Immunology & Inflammation,CD markers,Stem Cells,Endothelial Progenitors,MCAM

Molecular Weight

57 kDa/71 kDa

Gene ID

4162

UniProt

P43121