MCAM antibody (AA 447-646)
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- Target See all MCAM Antibodies
- MCAM (Melanoma Cell Adhesion Molecule (MCAM))
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Binding Specificity
- AA 447-646
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MCAM antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
- Sequence
- VLNLSCEASG HPRPTISWNV NGTASEQDQD PQRVLSTLNV LVTPELLETG VECTASNDLG KNTSILFLEL VNLTTLTPDS NTTTGLSTST ASPHTRANST STERKLPEPE SRGVVIVAVI VCILVLAVLG AVLYFLYKKG KLPCRRSGKQ EITLPPSRKS ELVVEVKSDK LPEEMGLLQG SSGDKRAPGD QGEKYIDLRH
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 447-646 of human CD146/CD146/MCAM (NP_006491.2).
- Isotype
- IgG
- Top Product
- Discover our top product MCAM Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- MCAM (Melanoma Cell Adhesion Molecule (MCAM))
- Alternative Name
- MCAM (MCAM Products)
- Background
- Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.,MCAM,CD146,MUC18,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cell Adhesion Molecules,Cytoskeleton,Immunology & Inflammation,CD markers,Stem Cells,Endothelial Progenitors,MCAM
- Molecular Weight
- 57 kDa/71 kDa
- Gene ID
- 4162
- UniProt
- P43121
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