EFHA1 antibody (AA 50-150)

Catalog No. ABIN6143833

Product Details anti-EFHA1 Antibody

Target: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Binding Specificity: AA 50-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EFHA1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AWHHSRVSVA ARDGSFTVSA QKNVEHGIIY IGKPSLRKQR FMQFSSLEHE GEYYMTPRDF LFSVMFEQME RKTSVKKLTK KDIEDTLSGI QTAGCGSTFF R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human MICU2 (NP_689939.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EFHA1

Target: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Alternative Name: MICU2 (EFHA1 Products)

Synonyms: 1110008L20Rik antibody, EFHA1 antibody, Efha1 antibody, RGD1309934 antibody, Smhs2 antibody, 4833427E09Rik antibody, AU041871 antibody, mitochondrial calcium uptake 2 antibody, MICU2 antibody, Micu2 antibody

Background: Key regulator of mitochondrial calcium uniporter (MCU required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.,MICU2,1110008L20Rik,EFHA1,Cell Biology & Developmental Biology,MICU2

Molecular Weight: 49 kDa

Gene ID: 221154

UniProt: Q8IYU8