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MORF4L1 antibody (AA 1-100)

The Rabbit Polyclonal anti-MORF4L1 antibody has been validated for WB. It is suitable to detect MORF4L1 in samples from Human.
Catalog No. ABIN6222866

Quick Overview for MORF4L1 antibody (AA 1-100) (ABIN6222866)

Target

See all MORF4L1 Antibodies
MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This MORF4L1 antibody is un-conjugated

Application

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Western Blotting (WB)
  • Binding Specificity

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    AA 1-100

    Sequence

    MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN KNWDEWVPES RVLKYVDTNL QKQRELQKAN QEQYAEGKMR GAAPGKKTSG

    Cross-Reactivity

    Human, Mouse, Rat

    Characteristics

    Polyclonal Antibodies

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MORF4L1 (NP_006782.1).

    Isotype

    IgG
  • Application Notes

    WB,1:500 - 1:2000

    Comment

    HIGH QUALITY

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

    Alternative Name

    MORF4L1

    Background

    Component of the NuA4 histone acetyltransferase (HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR and resistance to mitomycin C (MMC. Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.,MORF4L1,Eaf3,FWP006,HsT17725,MEAF3,MORFRG15,MRG15,S863-6,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,MORF4L1

    Molecular Weight

    26 kDa/37 kDa/41 kDa

    Gene ID

    10933

    UniProt

    Q9UBU8

    Pathways

    Chromatin Binding
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