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CCR5 antibody
CCR5
Reactivity: Human
WB, FACS, IP, IHC (p), EIA
Host: Mouse
Monoclonal
T21-8
unconjugated
Product Details anti-CCR5 Antibody
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Target
See all CCR5 Antibodies
CCR5
(Chemokine (C-C Motif) Receptor 5 (CCR5))
Reactivity
All reactivities for CCR5 antibodies
Human
Host
All hosts for CCR5 antibodies
Mouse
Clonality
All clonalities for CCR5 antibodies
Monoclonal
Conjugate
All conjugates for CCR5 antibodies
This CCR5 antibody is un-conjugated
Application
All applications for CCR5 antibodies
Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Specificity
Recognizes C-C Chemokine Receptor 5 (CCR5)
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Affinity Chromatography
Immunogen
Human CCR5
Clone
T21-8
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Aqeous buffer containing 0.09 % Sodium Azide as preservative and may contain carrier protein/stabilizer
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for CCR5
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Target
CCR5
(Chemokine (C-C Motif) Receptor 5 (CCR5))
Alternative Name
CD195 / CCR5 (CCR5 Products )
Synonyms
CC-CKR-5 antibody, CCCKR5 antibody, CCR-5 antibody, CD195 antibody, CKR-5 antibody, CKR5 antibody, CMKBR5 antibody, IDDM22 antibody, Ckr5 antibody, Cmkbr5 antibody, CCR1-L antibody, GPCR antibody, CCR5 antibody, AM4-7 antibody, C-C motif chemokine receptor 5 (gene/pseudogene) antibody, chemokine (C-C motif) receptor 5 antibody, C-C motif chemokine receptor 5 antibody, CCR5 antibody, Ccr5 antibody
Background
Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a number of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T lymphocytes and by monocytes. CD195 is rapidly phosphorylated within the C-terminal domain upon ligand stimulation. Recent studies suggest that phosphorylation at Ser337 is mediated by Protein kinase C, whereas phosphorylation at Ser349 is mediated by GPCR kinases.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor
Gene ID
1234
NCBI Accession
NP_000570
UniProt
P51681
Pathways
Cellular Response to Molecule of Bacterial Origin , cAMP Metabolic Process , Regulation of Cell Size
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