MR1 antibody (AA 20-260)

Catalog No. ABIN6143983

The Rabbit Polyclonal anti-MR1 antibody (ABIN6143983) specifically detects MR1 in WB and IF. The antibody is reactive with Human samples.

Quick Overview for MR1 antibody (AA 20-260) (ABIN6143983)

Target: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-MR1 Antibody

Binding Specificity: AA 20-260

Sequence: SDSRTHSLRY FRLGVSDPIH GVPEFISVGY VDSHPITTYD SVTRQKEPRA PWMAENLAPD HWERYTQLLR GWQQMFKVEL KRLQRHYNHS DNVAHTIKQA WEANQHELLY QKNWLEEECI AWLKRFLEYG KDTLQRTEPP LVRVNRKETF PGVTALFCKA HGFYPPEIYM TWMKNGEEIV QEIDYGDILP SGDGTYQAWA SIELDPQSSN LYSCHVEHCG VHMVLQVPQE SETIPLVMKA V

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human MR1 (NP_001181928.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MR1

Target: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Alternative Name: MR1

Background: MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome.,MR1,HLALS,Immunology & Inflammation,MR1

Molecular Weight: 25 kDa/28 kDa/34 kDa/39 kDa

Gene ID: 3140

UniProt: Q95460

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints