NUMB antibody (AA 521-640)

Catalog No. ABIN6144943

The Rabbit Polyclonal anti-NUMB antibody has been validated for WB, IHC and IF. It is suitable to detect NUMB in samples from Human.

Quick Overview for NUMB antibody (AA 521-640) (ABIN6144943)

Target: NUMB (Numb Homolog (NUMB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NUMB Antibody

Binding Specificity: AA 521-640

Sequence: SQMVANVFGT AGHPQAAHPH QSPSLVRQQT FPHYEASSAT TSPFFKPPAQ HLNGSAAFNG VDDGRLASAD RHTEVPTGTC PVDPFEAQWA ALENKSKQRT NPSPTNPFSS DLQKTFEIEL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 521-640 of human NUMB (NP_003735.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: NUMB

Background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants.,NUMB,C14orf41,S171,c14_5527,Signal Transduction,Cell Biology & Developmental Biology,Notch Signaling Pathway,Neuroscience,Stem Cells,NUMB

Molecular Weight: 37 kDa/48-70 kDa

Gene ID: 8650

UniProt: P49757

Pathways: Cell-Cell Junction Organization