PATZ1 antibody (AA 250-350)

Catalog No. ABIN6145252

This Rabbit Polyclonal antibody specifically detects PATZ1 in WB. It exhibits reactivity toward Human.

Quick Overview for PATZ1 antibody (AA 250-350) (ABIN6145252)

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PATZ1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PATZ1 Antibody

Binding Specificity: AA 250-350

Sequence: PFPSVASSAP PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_114440.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PATZ1

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Alternative Name: PATZ1

Background: The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.,PATZ1,MAZR,PATZ,RIAZ,ZBTB19,ZNF278,ZSG,dJ400N23,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,PATZ1

Molecular Weight: 57 kDa/69 kDa/74 kDa

Gene ID: 23598

UniProt: Q9HBE1