GDF15 antibody (AA 40-243)

Catalog No. ABIN6145370

This Rabbit Polyclonal antibody specifically detects GDF15 in WB. It exhibits reactivity toward Human.

Quick Overview for GDF15 antibody (AA 40-243) (ABIN6145370)

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF15 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GDF15 Antibody

Binding Specificity: AA 40-243

Sequence: EGPALRRSYW RHLRRLVLGP PEPPFSHVCQ VGDPVLRGVA APVERAQLGG PELQRLTQRL VQVMRRRRCV GLSAPQLGVP RQVLALELPE ALCRECPPRQ RALRQMEPFP LRVFVNPSLR VLDSRLVTFP EGCESVAGFL ACVPRFQAVQ ISGLDPNGEQ VVWQASGWAA RIIQHEMDHL QGCLFIDKMD SRTFTNVYWM KVND

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-243 of human PDF (NP_071736.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GDF15

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Alternative Name: PDF

Background: Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.,PDF,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Mitochondrial translation,Amino acid metabolism,Nucleotide metabolism,PDF

Molecular Weight: 27 kDa

Gene ID: 64146

UniProt: Q9HBH1

Pathways: SARS-CoV-2 Protein Interactome