PIAS4 antibody (AA 60-260)

Catalog No. ABIN6145602

This anti-PIAS4 antibody is a Rabbit Polyclonal antibody detecting PIAS4 in WB. Suitable for Human.

Quick Overview for PIAS4 antibody (AA 60-260) (ABIN6145602)

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIAS4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PIAS4 Antibody

Binding Specificity: AA 60-260

Sequence: ELYETRYAKK NSEPAPQPHR PLDPLTMHST YDRAGAVPRT PLAGPNIDYP VLYGKYLNGL GRLPAKTLKP EVRLVKLPFF NMLDELLKPT ELVPQNNEKL QESPCIFALT PRQVELIRNS RELQPGVKAV QVVLRICYSD TSCPQEDQYP PNIAVKVNHS YCSVPGYYPS NKPGVEPKRP CRPINLTHLM YLSSATNRIT V

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-260 of human PIAS4 (NP_056981.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PIAS4

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Alternative Name: PIAS4

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.,PIAS4,PIAS-gamma,PIASY,Piasg,ZMIZ6,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,NF-kB Signaling Pathway,PIAS4

Molecular Weight: 56 kDa

Gene ID: 51588

UniProt: Q8N2W9

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus