PSMB3 antibody (AA 1-205)

Catalog No. ABIN6146317

Product Details anti-PSMB3 Antibody

Target: PSMB3 (Proteasome Subunit beta 3 (PSMB3))

Binding Specificity: AA 1-205

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV SGMGVIVHII EKDKITTRTL KARMD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human PSMB3 (NP_002786.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PSMB3

Target: PSMB3 (Proteasome Subunit beta 3 (PSMB3))

Alternative Name: PSMB3 (PSMB3 Products)

Synonyms: HC10-II antibody, AL033320 antibody, C10-II antibody, PSB3 antibody, psmb3 antibody, wu:fb11d10 antibody, wu:fu88b08 antibody, zgc:56374 antibody, DDBDRAFT_0190542 antibody, DDBDRAFT_0232932 antibody, DDB_0190542 antibody, DDB_0232932 antibody, proteasome subunit beta 3 antibody, proteasome (prosome, macropain) subunit, beta type 3 antibody, proteasome subunit C10-11 antibody, proteasome subunit beta type-3 antibody, proteasome subunit beta 3 S homeolog antibody, 20S proteasome subunit beta-3 antibody, PSMB3 antibody, Psmb3 antibody, LOC100135869 antibody, LOC399377 antibody, psmb3.S antibody, psmb3 antibody, psmB3 antibody

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants,PSMB3,HC10-II,Cell Biology & Developmental Biology,Ubiquitin,PSMB3

Molecular Weight: 22 kDa

Gene ID: 5691

UniProt: P49720

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Cell RedoxHomeostasis, Lipid Metabolism