RBPJ antibody (AA 1-260)

Catalog No. ABIN6146805

Product Details anti-RBPJ Antibody

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Binding Specificity: AA 1-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBPJ antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MGGCRKFGER PPPKRLTREA MRNYLKERGD QTVLILHAKV AQKSYGNEKR FFCPPPCVYL MGSGWKKKKE QMERDGCSEQ ESQPCAFIGI GNSDQEMQQL NLEGKNYCTA KTLYISDSDK RKHFMLSVKM FYGNSDDIGV FLSKRIKVIS KPSKKKQSLK NADLCIASGT KVALFNRLRS QTVSTRYLHV EGGNFHASSQ QWGAFFIHLL DDDESEGEEF TVRDGYIHYG QTVKLVCSVT GMALPRLIIR KVDKQTALLD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RBPJKK (NP_976028.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RBPJ

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Alternative Name: RBPJ (RBPJ Products)

Background: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.,RBPJ,AOS3,CBF1,IGKJRB,IGKJRB1,KBF2,RBP-J,RBPJK,RBPSUH,SUH,csl,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,Cell Biology & Developmental Biology,Notch Signaling Pathway,Neuroscience,Stem Cells,RBPJ

Molecular Weight: 45 kDa/47 kDa/51 kDa/54 kDa/55 kDa

Gene ID: 3516

UniProt: Q06330

Pathways: Notch Signaling, Stem Cell Maintenance, Smooth Muscle Cell Migration