REST antibody (AA 760-1060)

Catalog No. ABIN6146869

The Rabbit Polyclonal anti-REST antibody has been validated for IF. It is suitable to detect REST in samples from Human.

Quick Overview for REST antibody (AA 760-1060) (ABIN6146869)

Target: REST (RE1-Silencing Transcription Factor (REST))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This REST antibody is un-conjugated

Application: Immunofluorescence (IF)

Product Details anti-REST Antibody

Binding Specificity: AA 760-1060

Sequence: PVKIELSPPI EVVQKEPVQM ELSPPMGVVQ KEPAQREPPP PREPPLHMEP ISKKPPLRKD KKEKSNMQSE RARKEQVLIE VGLVPVKDSW LLKESVSTED LSPPSPPLPK ENLREEASGD QKLLNTGEGN KEAPLQKVGA EEADESLPGL AANINESTHI SSSGQNLNTP EGETLNGKHQ TDSIVCEMKM DTDQNTRENL TGINSTVEEP VSPMLPPSAV EEREAVSKTA LASPPATMAA NESQEIDEDE GIHSHEGSDL SDNMSEGSDD SGLHGARPVP QESSRKNAKE ALAVKAAKGD F

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 760-1060 of human REST/NRSF (NP_001180437.1).

Isotype: IgG

Application Details

Application Notes: IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for REST

Target: REST (RE1-Silencing Transcription Factor (REST))

Alternative Name: REST

Background: This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described,REST,NRSF,WT6,XBR,Epigenetics & Nuclear Signaling,Transcription Factors,Neuroscience,Neurodegenerative Diseases,REST

Molecular Weight: 35 kDa/36 kDa/119 kDa/121 kDa

Gene ID: 5978

UniProt: Q13127

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity