NR1D1 antibody (AA 1-615)

Catalog No. ABIN614695

This Mouse Monoclonal antibody specifically detects NR1D1 in WB, IF, IHC (p) and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for NR1D1 antibody (AA 1-615) (ABIN614695)

Target: NR1D1 (Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This NR1D1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 4F6

Product Details anti-NR1D1 Antibody

Binding Specificity: AA 1-615

Specificity: This antibody recognizes Nuclear Receptor Rev-ErbA Alpha (NR1D1).

Purification: Protein A Chromatography

Immunogen: Recombinant protein, NR1D1 (AAH56148, 1 a.a. ~ 615 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Genename: NR1D1

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NR1D1

Target: NR1D1 (Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1))

Alternative Name: NR1D1

Background: Rev-erbA alpha, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). Rev-erbA alpha is a target of Nuclear Receptor ROR Alpha (Delerive et al. 2002), and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Recently Reb-erbA alpha has been shown to affect circadian rhythms by regulating cyclic Bmal1 transcription ( Preitner et al. 2002, Ueda et al. 2002). Mice lacking Rev-erbA alpha show abnormal postnatal cerebellar development.Synonyms: EAR1, HREV, Nuclear receptor subfamily 1 group D member 1, Rev-erbA-alpha, THRAL, V-erbA-related protein EAR-1

Gene ID: 9572

NCBI Accession: NP_068370

UniProt: P20393

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha