SF3B2 antibody (AA 616-895)

Catalog No. ABIN6147666

Product Details anti-SF3B2 Antibody

Target: SF3B2 (Splicing Factor 3b, Subunit 2, 145kDa (SF3B2))

Binding Specificity: AA 616-895

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SF3B2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: SLGMPVGPNA HKVPPPWLIA MQRYGPPPSY PNLKIPGLNS PIPESCSFGY HAGGWGKPPV DETGKPLYGD VFGTNAAEFQ TKTEEEEIDR TPWGELEPSD EESSEEEEEE ESDEDKPDET GFITPADSGL ITPGGFSSVP AGMETPELIE LRKKKIEEAM DGSETPQLFT VLPEKRTATV GGAMMGSTHI YDMSTVMSRK GPAPELQGVE VALAPEELEL DPMAMTQKYE EHVREQQAQV EKEDFSDMVA EHAAKQKQKK RKAQPQDSRG GSKKYKEFKF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 616-895 of human SF3B2 (NP_006833.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SF3B2

Target: SF3B2 (Splicing Factor 3b, Subunit 2, 145kDa (SF3B2))

Alternative Name: SF3B2 (SF3B2 Products)

Background: This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.,SF3B2,Cus1,SAP145,SF3B145,SF3b1,SF3b150,Epigenetics & Nuclear Signaling,RNA Binding,SF3B2

Molecular Weight: 100 kDa

Gene ID: 10992

UniProt: Q13435