HDAC4 antibody

Catalog No. ABIN6147718

The Rabbit Monoclonal anti-HDAC4 antibody is suitable to detect HDAC4 in samples from Human. It has been validated for WB.

Quick Overview for HDAC4 antibody (ABIN6147718)

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HDAC4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HDAC4 Antibody

Cross-Reactivity: Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human HDAC4

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Alternative Name: HDAC4

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008],AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA,Cardiovascular,Cell Biology & Developmental Biology,Cell Cycle,Epigenetics & Nuclear Signaling,G1/S Checkpoint,Heart,Heart_Hypertrophy,Immunology & Inflammation,NF-kB Signaling Pathway,Notch Signaling Pathway,Nuclear Receptor Signaling,Signal Transduction,Stem Cells,Wnt/β-Catenin Signaling Pathway,HDAC4

Molecular Weight: 140 kDa

Gene ID: 9759

UniProt: P56524

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process