SIRPA antibody (AA 395-504)

Catalog No. ABIN6147780

This anti-SIRPA antibody is a Rabbit Polyclonal antibody detecting SIRPA in WB and IF. Suitable for Human.

Quick Overview for SIRPA antibody (AA 395-504) (ABIN6147780)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRPA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-SIRPA Antibody

Binding Specificity: AA 395-504

Sequence: RIRQKKAQGS TSSTRLHEPE KNAREITQDT NDITYADLNL PKGKKPAPQA AEPNNHTEYA SIQTSPQPAS EDTLTYADLD MVHLNRTPKQ PAPKPEPSFS EYASVQVPRK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 395-504 of human CD172a/SIRPalpha (NP_542970.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Alternative Name: SIRPA

Background: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.,SIRPA,BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS1,SIRP,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Immunology & Inflammation,CD markers,Neuroscience,Cell Type Marker,Cardiovascular,Neuron marker,Synapse marker,SIRPA

Molecular Weight: 54 kDa/55 kDa

Gene ID: 140885

UniProt: P78324