SIRT3 antibody (C-Term)

Catalog No. ABIN6147792

The Rabbit Polyclonal anti-SIRT3 antibody has been validated for WB, IHC and IP. It is suitable to detect SIRT3 in samples from Human. There is 1 publication available.

Quick Overview for SIRT3 antibody (C-Term) (ABIN6147792)

Target: SIRT3 (Sirtuin 3 (SIRT3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-SIRT3 Antibody

Binding Specificity: C-Term

Sequence: QRFLLHVVDF PMADLLLILG TSLEVEPFAS LTEAVRSSVP RLLINRDLVG PLAWHPRSRD VAQLGDVVHG VESLVELLGW TEEMRDLVQR ETGKLDGPDK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human SIRT3 (NP_036371.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:500

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SIRT3 antibody (ABIN6147792)

Xu, Gao, Zhang, Wei, Chen, Dai, Zeng, Zhao: "SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 7296092, (2017) (PubMed).

Target Details for SIRT3

Target: SIRT3 (Sirtuin 3 (SIRT3))

Alternative Name: SIRT3

Background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.,SIRT3,SIR2L3,sirtuin 3,Epigenetics & Nuclear Signaling,SIRT3

Molecular Weight: 28 kDa/43 kDa

Gene ID: 23410

UniProt: Q9NTG7