SMAD4 antibody (AA 160-450)

Catalog No. ABIN6148088

This Rabbit Polyclonal antibody specifically detects SMAD4 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for SMAD4 antibody (AA 160-450) (ABIN6148088)

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SMAD4 Antibody

Binding Specificity: AA 160-450

Sequence: DEYVHDFEGQ PSLSTEGHSI QTIQHPPSNR ASTETYSTPA LLAPSESNAT STANFPNIPV ASTSQPASIL GGSHSEGLLQ IASGPQPGQQ QNGFTGQPAT YHHNSTTTWT GSRTAPYTPN LPHHQNGHLQ HHPPMPPHPG HYWPVHNELA FQPPISNHPA PEYWCSIAYF EMDVQVGETF KVPSSCPIVT VDGYVDPSGG DRFCLGQLSN VHRTEAIERA RLHIGKGVQL ECKGEGDVWV RCLSDHAVFV QSYYLDREAG RAPGDAVHKI YPSAYIKVFD LRQCHRQMQQ Q

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 160-450 of human Smad4 (NP_005350.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMAD4

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Alternative Name: SMAD4

Background: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.,DPC4,JIP,MADH4,MYHRS,Smad4,SMAD4,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Tumor suppressors,Signal Transduction,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,G1/S Checkpoint,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Stem Cells,Cardiovascular,Hypoxia,Heart,Cardiogenesis,Hypertrophy,SMADs,SMAD4

Molecular Weight: 60 kDa

Gene ID: 4089

UniProt: Q13485

Pathways: Cell Division Cycle, Chromatin Binding, Autophagy