SMPD3 antibody (AA 416-655)

Catalog No. ABIN6148146

This Rabbit Polyclonal antibody specifically detects SMPD3 in WB. It exhibits reactivity toward Human.

Quick Overview for SMPD3 antibody (AA 416-655) (ABIN6148146)

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMPD3 Antibody

Binding Specificity: AA 416-655

Sequence: MDVAYHCYPN KCNDDALASK GALFLKVQVG STPQDQRIVG YIACTHLHAP QEDSAIRCGQ LDLLQDWLAD FRKSTSSSSA ANPEELVAFD VVCGDFNFDN CSSDDKLEQQ HSLFTHYRDP CRLGPGEEKP WAIGTLLDTN GLYDEDVCTP DNLQKVLESE EGRREYLAFP TSKSSGQKGR KELLKGNGRR IDYMLHAEEG LCPDWKAEVE EFSFITQLSG LTDHLPVAMR LMVSSGEEEA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 416-655 of human SMPD3 (NP_061137.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMPD3

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Alternative Name: SMPD3

Background: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs such as phosphatidylserine (PS and phosphatidic acid (PA that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity.,SMPD3,NSMASE2,Cell Biology & Developmental Biology,Apoptosis,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Oligodendrocyte marker,Neuron marker,SMPD3

Molecular Weight: 70 kDa/71 kDa

Gene ID: 55512

UniProt: Q9NY59

Pathways: Hormone Transport