SORL1 antibody (AA 2065-2214)

Catalog No. ABIN6148279

Product Details anti-SORL1 Antibody

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Binding Specificity: AA 2065-2214

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DSAMNITAYL GNTTDNFFKI SNLKMGHNYT FTVQARCLFG NQICGEPAIL LYDELGSGAD ASATQAARST DVAAVVVPIL FLILLSLGVG FAILYTKHRR LQSSFTAFAN SHYSSRLGSA IFSSGDDLGE DDEDAPMITG FSDDVPMVIA

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2065-2214 of human SORL1 (NP_003096.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: SORL1 (SORL1 Products)

Background: This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease.,SORL1,C11orf32,LR11,LRP9,SORLA,SorLA-1,gp250,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Microtubules,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Lipid Metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,SORL1

Molecular Weight: 248 kDa

Gene ID: 6653

UniProt: Q92673

Pathways: Smooth Muscle Cell Migration