TAB2 antibody (AA 350-693)

Catalog No. ABIN6148797

This Rabbit Polyclonal antibody specifically detects TAB2 in WB. It exhibits reactivity toward Human.

Quick Overview for TAB2 antibody (AA 350-693) (ABIN6148797)

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TAB2 Antibody

Binding Specificity: AA 350-693

Sequence: STSSSVNSQT LNRNQPTVYI AASPPNTDEL MSRSQPKVYI SANAATGDEQ VMRNQPTLFI STNSGASAAS RNMSGQVSMG PAFIHHHPPK SRAIGNNSAT SPRVVVTQPN TKYTFKITVS PNKPPAVSPG VVSPTFELTN LLNHPDHYVE TENIQHLTDP TLAHVDRISE TRKLSMGSDD AAYTQALLVH QKARMERLQR ELEIQKKKLD KLKSEVNEME NNLTRRRLKR SNSISQIPSL EEMQQLRSCN RQLQIDIDCL TKEIDLFQAR GPHFNPSAIH NFYDNIGFVG PVPPKPKDQR SIIKTPKTQD TEDDEGAQWN CTACTFLNHP ALIRCEQCEM PRHF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-693 of human TAB2 (NP_001278963.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TAB2

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Alternative Name: TAB2

Background: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.,TAB2,CHTD2,MAP3K7IP2,TAB-2,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,TAB2

Molecular Weight: 58 kDa/76 kDa

Gene ID: 23118

UniProt: Q9NYJ8

Pathways: TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway