TPP1 antibody (AA 284-563)

Catalog No. ABIN6149442

The Rabbit Polyclonal anti-TPP1 antibody has been validated for WB. It is suitable to detect TPP1 in samples from Human.

Quick Overview for TPP1 antibody (AA 284-563) (ABIN6149442)

Target: TPP1 (Tripeptidyl Peptidase I (TPP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TPP1 Antibody

Binding Specificity: AA 284-563

Sequence: GANISTWVYS SPGRHEGQEP FLQWLMLLSN ESALPHVHTV SYGDDEDSLS SAYIQRVNTE LMKAAARGLT LLFASGDSGA GCWSVSGRHQ FRPTFPASSP YVTTVGGTSF QEPFLITNEI VDYISGGGFS NVFPRPSYQE EAVTKFLSSS PHLPPSSYFN ASGRAYPDVA ALSDGYWVVS NRVPIPWVSG TSASTPVFGG ILSLINEHRI LSGRPPLGFL NPRLYQQHGA GLFDVTRGCH ESCLDEEVEG QGFCSGPGWD PVTGWGTPNF PALLKTLLNP

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 284-563 of human TPP1 (NP_000382.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TPP1

Target: TPP1 (Tripeptidyl Peptidase I (TPP1))

Alternative Name: TPP1

Background: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.,TPP1,CLN2,GIG1,LPIC,SCAR7,TPP-1,Cell Biology & Developmental Biology,Ubiquitin,Neuroscience,Neurodegenerative Diseases,TPP1

Molecular Weight: 34 kDa/61 kDa

Gene ID: 1200

UniProt: O14773

Pathways: Cell Division Cycle, ER-Nucleus Signaling