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Zona Pellucida Glycoprotein 3 antibody (AA 250-350)

ZP3 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6150536
  • Target See all Zona Pellucida Glycoprotein 3 (ZP3) Antibodies
    Zona Pellucida Glycoprotein 3 (ZP3)
    Binding Specificity
    • 9
    • 8
    • 6
    • 2
    • 1
    AA 250-350
    Reactivity
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    Human
    Host
    • 20
    • 2
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This Zona Pellucida Glycoprotein 3 antibody is un-conjugated
    Application
    • 20
    • 14
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    AFKVPRPGPD TLQFTVDVFH FANDSRNMIY ITCHLKVTLA EQDPDELNKA CSFSKPSNSW FPVEGSADIC QCCNKGDCGT PSHSRRQPHV MSQWSRSASR N
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 250-350 of human ZP3 (NP_001103824.1).
    Isotype
    IgG
    Top Product
    Discover our top product ZP3 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Zona Pellucida Glycoprotein 3 (ZP3)
    Alternative Name
    ZP3 (ZP3 Products)
    Synonyms
    ZP3A antibody, ZP3B antibody, ZPC antibody, Zp-3 antibody, zp3.2 antibody, Zp-3B antibody, zona pellucida glycoprotein 3 antibody, zona pellucida sperm-binding protein 3 antibody, ZP3 antibody, zp3 antibody, Zp3 antibody
    Background
    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.,ZP3,ZP3A,ZP3B,ZPC,Zp-3,ZP3
    Molecular Weight
    41 kDa/47 kDa
    Gene ID
    7784
    UniProt
    P21754
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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