PDE4B antibody (C-Term)

Catalog No. ABIN615425

Product Details anti-PDE4B Antibody

Target: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This PDE4B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: C-DIDIATEDKS PVDT

Specificity: This antibody detects PDE4B (C-term) and is expected to recognize all reported isoforms.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide from C-terminus of Human PDE4B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline buffer, pH ~7.3 containing 0.5 % BSA as stabilizer and 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PDE4B

Target: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Alternative Name: PDE4B (PDE4B Products)

Synonyms: dpde4 antibody, pde4b5 antibody, pdeivb antibody, Dpde4 antibody, R74983 antibody, dunce antibody, PDE4/IVb antibody, Pde4B1 antibody, Pde4B2 antibody, Pde4B3 antibody, Pde4B4 antibody, DPDE4 antibody, PDE4B5 antibody, PDEIVB antibody, phosphodiesterase 4B antibody, phosphodiesterase 4B, cAMP specific antibody, phosphodiesterase 4B S homeolog antibody, pde4b antibody, PDE4B antibody, Pde4b antibody, pde4b.S antibody

Background: Phosphodiesterase 4B, a cAMP-specific phosphodiesterase, regulates pro-inflammatory and immune cells, and may function in learning, leukemia, memory (or other brain functions), and penile erectile dysfunction. PDE4B activity is inhibited by rolipram. At least three PDE4B isoforms, produced by alternative splicing, have been reported.Synonyms: 5'-cyclic phosphodiesterase 4B, DPDE4, EC=3.1.4.17, PDE32, PDE4B, cAMP-specific 3'

Gene ID: 5142

NCBI Accession: NP_001032416

UniProt: Q07343

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction