alpha 1 Adrenergic Receptor antibody (AA 206-270)

Catalog No. ABIN615469

This Rabbit Polyclonal antibody specifically detects alpha 1 Adrenergic Receptor in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for alpha 1 Adrenergic Receptor antibody (AA 206-270) (ABIN615469)

Target: alpha 1 Adrenergic Receptor (ADRA1A) (Adrenoceptor alpha 1A (ADRA1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha 1 Adrenergic Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-alpha 1 Adrenergic Receptor Antibody

Binding Specificity: AA 206-270

Specificity: This antibody detects Alpha-1A adrenergic receptor.

Cross-Reactivity (Details): Species reactivity (expected):The antibody is predicted to cross-react with the following species based on their respective sequence homologies: Mouse (100 %), Rat (100 %), Rabbit (100 %), Cow (100 %), Monkey (100 %). Cross-reactivity has not been experimentally confirmed at this time.
Species reactivity (tested):Human

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide corresponding to a region within amino acids 206 and 270 of Human Alpha-1A adrenergic receptor

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.0 containing 1 % BSA and 20 % Glycerol as stabilizer and 0.01 % Thimerosal as preservative

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C. Dilute only prior to immediate use.

Target Details for alpha 1 Adrenergic Receptor

Target: alpha 1 Adrenergic Receptor (ADRA1A) (Adrenoceptor alpha 1A (ADRA1A))

Alternative Name: alpha-1A Adrenergic Receptor

Background: The alpha 1c- Adrenergic Receptor, also known as alpha 1a-adrenoceptor, is activated by epinephrine and norepinephrine. This receptor mediates calcium release upon ligand binding. The alpha 1-c adrenoceptor is one of three subtypes of alpha 1-adrenergic receptor (alpha 1 c/a, alpha 1b, and alpha 1d). The alpha 1c receptor couples to phospholipase C via a GTP-binding protein insensitive to pertussis toxin. Three isoforms are generated by alternative splicing. However, the corresponding isoforms of the protein have similar ligand-binding properties, effector coupling, and tissue distribution.Synonyms: ADRA1A, ADRA1C, Alpha 1A-adrenoceptor, Alpha 1A-adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c

Gene ID: 148

NCBI Accession: NP_000671

UniProt: P35348

Pathways: AMPK Signaling