TLR7 antibody (AA 900-950)

Catalog No. ABIN615823

This Rabbit Polyclonal antibody specifically detects TLR7 in WB and IHC (p). It exhibits reactivity toward Human, Mouse, Rat, Monkey, Dog, Cow and Horse.

Quick Overview for TLR7 antibody (AA 900-950) (ABIN615823)

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Reactivity: Human, Mouse, Rat, Monkey, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TLR7 Antibody

Binding Specificity: AA 900-950

Specificity: This antibody reacts to Toll-like Receptor 7 (TLR7).

Purification: Protein G Chromatography

Immunogen: Synthetic peptide - KLH conjugated, A portion of amino acids 900-950 of human TLR7 Genename: TLR7

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: PBS containing 0.2 % gelatin and 0.05 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TLR7

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Alternative Name: TLR7

Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus. Activation of TLR7 by VSV results in stimulation of the immune response including IFNa secretion, suggesting the importance of TLR7 in virus recognition.Synonyms: Toll-like receptor 7

Gene ID: 51284

NCBI Accession: NP_057646

UniProt: Q9NYK1

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades