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HSPG antibody (CF®488A)

HSPG Reactivity: Human, Cow, Mouse, Fish, Monkey, Pig IHC (p), IF, FACS, IHC (f) Host: Rat Monoclonal A7L6 CF®488A
Catalog No. ABIN6159593
  • Target See all HSPG Antibodies
    HSPG (Heparan Sulphate Protoglycans (HSPG))
    Reactivity
    • 17
    • 12
    • 11
    • 8
    • 8
    • 8
    • 2
    Human, Cow, Mouse, Fish, Monkey, Pig
    Host
    • 11
    • 5
    • 4
    Rat
    Clonality
    • 16
    • 4
    Monoclonal
    Conjugate
    • 11
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HSPG antibody is conjugated to CF®488A
    Application
    • 12
    • 11
    • 10
    • 9
    • 8
    • 8
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Purpose
    Rat Monoclonal anti-Heparan Sulfate Proteoglycan (A7L6), CF488A Conjugate
    Characteristics
    This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. Primary antibodies are available purified, or with a selection of fluorescent CF ® dyes and other labels. CF ® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF ®405S and CF ®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Immunogen
    Murine EHS laminin preparation
    Clone
    A7L6
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product HSPG Primary Antibody
  • Application Notes
    Immunohistology formalin-fixed 1-2 μg/mL
    • Staining of formalin/paraffin tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Immunofluorescence 0.5-1 μg/mL
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Optimal dilution for a specific application should be determined by user
    Comment

    Breast carcinomas, squamous cell carcinomas.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    100 μg/mL
    Buffer
    PBS/0.1 % BSA/0.05 % azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from light
  • Target
    HSPG (Heparan Sulphate Protoglycans (HSPG))
    Alternative Name
    Heparan Sulfate Proteoglycan (HSPG Products)
    Synonyms
    CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, CD44 molecule (Indian blood group) antibody, glypican 3 antibody, CD44 antigen antibody, CD44 antibody, GPC3 antibody, Cd44 antibody
    Background
    Heparan sulfate proteoglycan of basement membrane, HSPG, Hspg2, LG3 peptide, Perlecan, PLC, SJS1
    Molecular Weight
    >400 kDa
    Gene ID
    3339, 562227
    UniProt
    P98160
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