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KRT15 antibody (Keratin 15) (C-Term) (CF®594) Primary Antibody

KRT15 Reactivity: Human, Rat, Cow FACS, IF, IHC (fro), WB Host: Mouse Monoclonal LHK15 CF®594
Catalog No. ABIN6172498
$270.77
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  • Target See all KRT15 Antibodies
    KRT15
    Binding Specificity
    • 27
    • 15
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 100
    • 43
    • 32
    • 26
    • 2
    Human, Rat, Cow
    Host
    • 63
    • 37
    • 5
    Mouse
    Clonality
    • 58
    • 47
    Monoclonal
    Conjugate
    • 50
    • 13
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KRT15 antibody is conjugated to CF®594
    Application
    • 65
    • 39
    • 29
    • 29
    • 21
    • 18
    • 18
    • 14
    • 14
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
    Purpose
    Mouse Monoclonal anti-Cytokeratin 15 (LHK15), CF594 Conjugate
    Characteristics
    Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Immunogen
    A 17 amino acids synthetic peptide from the C- terminal of Human Cytokeratin 15 (exact sequence is proprietary)
    Clone
    LHK15
    Isotype
    IgG2a kappa
  • Application Notes
    Immunohistology (frozen or formalin) 0.5-1 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Immunofluorescence 1-2 μg/mL
    • Western blotting 0.5-1 μg/mL
    • Optimal dilution for a specific application should be determined by user
    Comment

    A431 cells. Skin or Colon

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    100 μg/mL
    Buffer
    PBS/0.1 % BSA/0.05 % azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from light
  • Target
    KRT15
    Alternative Name
    Cytokeratin 15 (KRT15 Products)
    Synonyms
    xlk2, CK15, K15, K1CO, AI528832, Krt1-15, Ka15, wu:fa91c06, wu:fa95d04, zgc:55334, keratin 15, type I L homeolog, keratin 15, type I, keratin 15, krt15.L, krt15, KRT15, Krt15
    Background
    CK15, Cytokeratin 15, K1CO, Ka15, Keratin 15 basic, Keratin 15 beta, Keratin complex 1 acidic gene 15, Keratin type I cytoskeletal 15, KRT15, KRTB, KRTL15, Type I cytoskeletal 15, Type I keratin Ka15
    Molecular Weight
    52 kDa
    Gene ID
    3866, 654570
    UniProt
    P19012
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