beta Catenin antibody (pSer33, pSer37)

Catalog No. ABIN6241068

The Rabbit Polyclonal anti-beta Catenin antibody has been validated for WB. It is suitable to detect beta Catenin in samples from Human. There is 1 publication available.

Quick Overview for beta Catenin antibody (pSer33, pSer37) (ABIN6241068)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Catenin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42029

Product Details anti-beta Catenin Antibody

Binding Specificity: AA 19-41, pSer33, pSer37

Predicted Reactivity: B, Zf, M, Rat, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Phospho-beta-catenin (Ser33/37) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-41 amino acids from human beta-catenin .

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-beta Catenin antibody (ABIN6241068)

Zhuang, Wang, Wang, Ma, Han, Zou, Wu, Dong, Qu, Zang, Wu: "MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma." in: Cell death & disease, Vol. 8, Issue 5, pp. e2804, (2018) (PubMed).

Target Details for beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Alternative Name: beta-catenin

Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:< a href="http://www.uniprot.org/citations/17524503" target="_blank">17524503, PubMed:< a href="http://www.uniprot.org/citations/18077326" target="_blank">18077326, PubMed:< a href="http://www.uniprot.org/citations/18086858" target="_blank">18086858, PubMed:< a href="http://www.uniprot.org/citations/18957423" target="_blank">18957423, PubMed:< a href="http://www.uniprot.org/citations/21262353" target="_blank">21262353, PubMed:< a href="http://www.uniprot.org/citations/22647378" target="_blank">22647378, PubMed:< a href="http://www.uniprot.org/citations/22699938" target="_blank">22699938, PubMed:< a href="http://www.uniprot.org/citations/22155184" target="_blank">22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

Molecular Weight: 85497

UniProt: P35222

Pathways: Peptide Hormone Metabolism