DBC1 antibody

Catalog No. ABIN6241147

The Mouse Monoclonal anti-DBC1 antibody (ABIN6241147) specifically detects DBC1 in WB, IP and ICC. The antibody is reactive with Human and Mouse samples.

Quick Overview for DBC1 antibody (ABIN6241147)

Target: DBC1 (BRINP1) (Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This DBC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Product Details anti-DBC1 Antibody

Immunogen: Recombinant Protein

Application Details

Application Notes: IP: 1:500. WB: 1:500. ICC: 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for DBC1

Target: DBC1 (BRINP1) (Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1))

Alternative Name: DBC1

Background: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.

UniProt: Q8N163