Protein Phosphatase 4C antibody
This Mouse Monoclonal antibody specifically detects Protein Phosphatase 4C in WB, ICC and IHC. It exhibits reactivity toward Human.
Catalog No. ABIN6241238
$451.00
Plus shipping costs $50.00
100 μL
Shipping to:
United States
Delivery in 10 to 12 Business Days
Quick Overview for Protein Phosphatase 4C antibody (ABIN6241238)
Target
Protein Phosphatase 4C
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Conjugate
Un-conjugated
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
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Immunogen
- Recombinant Protein
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Application Notes
- WB: 1:200. IHC: 1:100. ICC: 1:200
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Restrictions
- For Research Use only
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Format
- Liquid
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Storage
- 4 °C,-20 °C
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- Protein Phosphatase 4C
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Background
- Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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UniProt
- P60510
Target
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