CBX3 antibody

Catalog No. ABIN6241538

This Mouse Monoclonal antibody specifically detects CBX3 in WB, IHC, IP and ICC. It exhibits reactivity toward Human and Mouse.

Quick Overview for CBX3 antibody (ABIN6241538)

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBX3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Product Details anti-CBX3 Antibody

Immunogen: Recombinant Protein

Application Details

Application Notes: IP: 1:500. WB: 1:1000. IHC: 1:100. ICC: 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for CBX3

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Alternative Name: HP1-gamma

Background: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

UniProt: Q13185