ANKRD15 antibody

Catalog No. ABIN6242162

This Mouse Monoclonal antibody specifically detects ANKRD15 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ANKRD15 antibody (ABIN6242162)

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ANKRD15 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1773CT634-49-61

Product Details anti-ANKRD15 Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This KANK1 antibody is generated from a mouse immunized with a recombinant protein of human KANK1.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Alternative Name: KANK1

Background: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity, the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia, the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading, the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Molecular Weight: 147289

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization