BRD4 antibody (C-Term)

Catalog No. ABIN6242208

The Rabbit Polyclonal anti-BRD4 antibody has been validated for IHC (p). It is suitable to detect BRD4 in samples from Human. There are 4+ publications available.

Quick Overview for BRD4 antibody (C-Term) (ABIN6242208)

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRD4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3422

Product Details anti-BRD4 Antibody

Binding Specificity: AA 1313-1342, C-Term

Predicted Reactivity: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BRD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1313~1342 amino acids from the C-terminal region of human BRD4.

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BRD4 antibody (ABIN6242208)

Yamada, Honma, Mochizuki, Goda: "BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver." in: Metabolism: clinical and experimental, Vol. 65, Issue 10, pp. 1478-88, (2017) (PubMed).

Sénéchal, Poirier, Coulombe, Laimins, Archambault: "Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4." in: Virology, Vol. 358, Issue 1, pp. 10-7, (2007) (PubMed).

Kurg, Tekkel, Abroi, Ustav: "Characterization of the functional activities of the bovine papillomavirus type 1 E2 protein single-chain heterodimers." in: Journal of virology, Vol. 80, Issue 22, pp. 11218-25, (2006) (PubMed).

Kurg, Sild, Ilves, Sepp, Ustav: "Association of bovine papillomavirus E2 protein with nuclear structures in vivo." in: Journal of virology, Vol. 79, Issue 16, pp. 10528-39, (2005) (PubMed).

Target Details for BRD4

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Alternative Name: BRD4

Background: BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. The gene has been implicated as the chromosome 19 target of translocation t(15,19)(q13,p13.1), which defines an upper respiratory tract carcinoma in young people.

Molecular Weight: 152219

NCBI Accession: NP_055114, NP_490597

UniProt: O60885

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interactome