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DPPA3 antibody (C-Term)

DPPA3 Reactivity: Human WB Host: Rabbit Polyclonal RB50716 unconjugated
Catalog No. ABIN6242290
  • Target See all DPPA3 Antibodies
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    Binding Specificity
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 145-179, C-Term
    Reactivity
    • 19
    • 12
    • 1
    • 1
    Human
    Host
    • 20
    • 1
    • 1
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DPPA3 antibody is un-conjugated
    Application
    • 8
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This DPPA3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 145-179 amino acids from the C-terminal region of human DPPA3.
    Clone
    RB50716
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DPPA3 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    Alternative Name
    DPPA3 (DPPA3 Products)
    Synonyms
    STELLA antibody, 2410075G02Rik antibody, PCG7 antibody, PGC7 antibody, Stella antibody, developmental pluripotency associated 3 antibody, developmental pluripotency-associated 3 antibody, DPPA3 antibody, Dppa3 antibody
    Background
    Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).
    Molecular Weight
    17851
    UniProt
    Q6W0C5
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