FOXN4 antibody (C-Term)

Catalog No. ABIN6242346

Product Details anti-FOXN4 Antibody

Target: FOXN4 (Forkhead Box N4 (FOXN4))

Binding Specificity: AA 436-470, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXN4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FOXN4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 436-470 amino acids from the C-terminal region of human FOXN4.

Clone: RB52411

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for FOXN4

Target: FOXN4 (Forkhead Box N4 (FOXN4))

Alternative Name: FOXN4 (FOXN4 Products)

Synonyms: whn antibody, whna antibody, forkhead box N4 antibody, forkhead box N4 S homeolog antibody, FOXN4 antibody, foxn4 antibody, Foxn4 antibody, foxn4.S antibody

Background: Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).

Molecular Weight: 55215

UniProt: Q96NZ1