Klotho antibody (C-Term)

Catalog No. ABIN6242420

This Rabbit Polyclonal antibody specifically detects Klotho in WB. It exhibits reactivity toward Human.

Quick Overview for Klotho antibody (C-Term) (ABIN6242420)

Target: Klotho (KL)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Klotho antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB55296

Product Details anti-Klotho Antibody

Binding Specificity: AA 284-315, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Klotho antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 284-315 amino acids from the C-terminal region of human Klotho.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for Klotho

Target: Klotho (KL)

Alternative Name: Klotho

Background: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).

Molecular Weight: 116181

UniProt: Q9UEF7

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding