MBD2 antibody (AA 10-228)

Catalog No. ABIN6242434

The Mouse Monoclonal anti-MBD2 antibody (Clone 1812CT625-9-45) (ABIN6242434) specifically detects MBD2 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for MBD2 antibody (AA 10-228) (ABIN6242434)

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MBD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1812CT625-9-45

Product Details anti-MBD2 Antibody

Binding Specificity: AA 10-228

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This MBD2 antibody is generated from a mouse immunized with a recombinant protein between 10-228 amino acids from human MBD2.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Alternative Name: MBD2

Background: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

Molecular Weight: 43255

UniProt: Q9UBB5

Pathways: Chromatin Binding