MELK antibody (AA 381-415)

Catalog No. ABIN6242438

This Rabbit Polyclonal antibody specifically detects MELK in WB. It exhibits reactivity toward Mouse.

Quick Overview for MELK antibody (AA 381-415) (ABIN6242438)

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MELK antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB51207

Product Details anti-MELK Antibody

Binding Specificity: AA 381-415

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Melk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 381-415 amino acids from the Central region of Mouse Melk.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for MELK

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Alternative Name: Melk

Background: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

Molecular Weight: 72729

UniProt: Q61846