WWP2 antibody (N-Term)

Catalog No. ABIN6242488

The Rabbit Polyclonal anti-WWP2 antibody (Clone RB51426) (ABIN6242488) specifically detects WWP2 in WB. The antibody is reactive with Human samples.

Quick Overview for WWP2 antibody (N-Term) (ABIN6242488)

Target: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWP2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB51426

Product Details anti-WWP2 Antibody

Binding Specificity: AA 218-252, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WWP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 218-252 amino acids from the N-terminal region of human WWP2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for WWP2

Target: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Alternative Name: WWP2

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation, in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation, in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2, the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Molecular Weight: 98912

UniProt: O00308

Pathways: Negative Regulation of Transporter Activity