WWP2 antibody (AA 145-367)

Catalog No. ABIN7161126

The Rabbit Polyclonal anti-WWP2 antibody is suitable to detect WWP2 in samples from Human. It has been validated for IHC and ELISA.

Quick Overview for WWP2 antibody (AA 145-367) (ABIN7161126)

Target: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-WWP2 Antibody

Binding Specificity: AA 145-367

Purpose: WWP2 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP2 protein (145-367AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WWP2

Target: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Alternative Name: WWP2

Background:

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by \\\'Lys-63\\\'-linked conjugation and promotes it to proteasomal degradation, in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation, in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2, the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Aliases: WWP2NEDD4-like E3 ubiquitin-protein ligase WWP2 antibody, EC 2.3.2.26 antibody, Atrophin-1-interacting protein 2 antibody, AIP2 antibody, HECT-type E3 ubiquitin transferase WWP2 antibody, WW domain-containing protein 2 antibody

UniProt: O00308

Pathways: Negative Regulation of Transporter Activity