RING1 antibody (C-Term)

Catalog No. ABIN6242605

This anti-RING1 antibody is a Rabbit Polyclonal antibody detecting RING1 in WB. Suitable for Human and Rat.

Quick Overview for RING1 antibody (C-Term) (ABIN6242605)

Target: RING1 (Ring Finger Protein 1 (RING1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RING1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB51604

Product Details anti-RING1 Antibody

Binding Specificity: AA 279-313, C-Term

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RING1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-313 amino acids from the C-terminal region of human RING1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for RING1

Target: RING1 (Ring Finger Protein 1 (RING1))

Alternative Name: RING1

Background: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Molecular Weight: 42429

UniProt: Q06587