HES1 antibody (AA 102-137)

Catalog No. ABIN6242801

This Rabbit Polyclonal antibody specifically detects HES1 in WB. It exhibits reactivity toward Mouse.

Quick Overview for HES1 antibody (AA 102-137) (ABIN6242801)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB50935

Product Details anti-HES1 Antibody

Binding Specificity: AA 102-137

Predicted Reactivity: X, B, H, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Hes1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 102-137 amino acids from the Central region of Mouse Hes1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Alternative Name: Hes1

Background: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).

Molecular Weight: 29749

UniProt: P35428

Pathways: DNA Damage Repair