PRKAB1 antibody

Catalog No. ABIN6243028

The Mouse Monoclonal anti-PRKAB1 antibody (Clone 1420CT832-86-25) (ABIN6243028) specifically detects PRKAB1 in WB. The antibody is reactive with Mouse and Rat samples.

Quick Overview for PRKAB1 antibody (ABIN6243028)

Target: PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))

Reactivity: Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRKAB1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1420CT832-86-25

Product Details anti-PRKAB1 Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This PRKAB1 antibody is generated from a mouse immunized with a recombinant of human PRKAB1.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for PRKAB1

Target: PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))

Alternative Name: PRKAB1

Background: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Molecular Weight: 30382

UniProt: Q9Y478

Pathways: AMPK Signaling, Warburg Effect