MME antibody (AA 492-525)

Catalog No. ABIN6243089

This Rabbit Polyclonal antibody specifically detects MME in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MME antibody (AA 492-525) (ABIN6243089)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB43677

Product Details anti-MME Antibody

Binding Specificity: AA 492-525

Predicted Reactivity: Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MME antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 492-525 amino acids from the Central region of human MME.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: MME

Target Type: Chemical

Background: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers.

Molecular Weight: 85514

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration