FZR1 antibody (AA 1-496)

Catalog No. ABIN6243204

The Mouse Monoclonal anti-FZR1 antibody has been validated for WB. It is suitable to detect FZR1 in samples from Human.

Quick Overview for FZR1 antibody (AA 1-496) (ABIN6243204)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FZR1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1621CT637-76-67

Product Details anti-FZR1 Antibody

Binding Specificity: AA 1-496

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Alternative Name: FZR

Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Molecular Weight: 55179

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA